Mystery-Virus/Rickettsial Infection/Deficiencies?

[GoldenTreePackGoats]

Update: 

I've continued to do testing on 2 of the 3 infected goats, due to over exerted resources I can't do all of them. 
Huck the most severe besides Yukon is showing normal kidney values 4 weeks after this disease process started, and his wbc are normalizing as well as an increase in total protein and rbc, liver values are also down and normalizing. He is bright, alert, interacting normally with both me and the herd.

Kivuli has also normalized in the kidney, and total protein values but her CBC's are showing an interesting trend, the cells themselves are "different/abnormal" and suggest viral, bacterial, or blood borne parasite. However she was one of the 2 we sampled for a viral panel at UC Davis which came back all negative, negative for lepto, negative for lyme (free add on test), neg anaplasmosis, nothing abnormal on nasal swab as far as bacteria. 

My understanding is that silent pneumonia can present itself without respiratory symptom and kills quickly I would think it would have shown up on the viral/bacterial panels between the 2 sick goats tested. 2 antibiotics were used (I don't know the first one, the second was nuflor), neither made a difference, a 3rd was added into the treatment plan at 19 days in for Huck and Kivu because of suspected anaplasmosis and they were declining to quickly to wait for results, oddly enough after I treated them with oxy-tet for anaplas. they started getting better, yet the test came back negative. 

In the past I've used doramectin with great success. At the end of May, 1/2 my herd tested great in their fecals, so for Yukon to have such a high epg of 2300 it has been assumed he was immune compromised for a while. I've been told to do a course of Ivermectin every 10 days for 4 doses at 1ml/40# incase there is a foreign parasite that invaded my herd, in which case they say it could be harboring itself anywhere and not show up in fecals. (remember the odd CBC pathology report suggesting blood borne parasite potentially). If it is a parasite or bacteria from the trail, it most likely came from the trail in the beginning of this thread, that would have given it enough time for to get my home dwelling does. There was tons of deer/elk tracks, feces, and fur on that trail but no known outbreaks of anything in the wild population that is known at this time.  

I was concerned that the banamine caused some of the problems until the one doe that wasn't treated with more than a single dose of banamine showed renal disease too. Idea's that were suggested about Yukon's staggering were that he had a fever  of 107 for 8 hours and than for the next 6 days after continued to spike (long nights of cold hosing goats, and sleeping in shifts), a fever too high for too long can cause brain damage, also his kidney values were elevated to 5 times higher than they should be, meaning all the toxins his body creates whether it was drugs I gave or his bodily functions wasn't being filtered and built in his system, I would stagger too. 

I will remember baytril and draxxin, after looking at the price I may not be able to convince my friend at the vet hospital to order me some but it never hurts to ask! I did post it on thegoatspot.net "hard hitting virus" if your interested in what others had to say. We treated with thiamine from the moment they became ill as a preventative for polio and appetite stimulant.

Many little things put together don't make sense, 6 yearlings living together 100% of the time, 2 didn't get ill (tested them too to make sure) one of them is a packer that has been on all the same trails, the other is direct sibling of Huck and Yukon. Then 2 bucklings 5 & 7 months housed in next door pen, no illness, even the little guy that survived aspiration pneumonia. Odd abnormalities in their blood work that doesn't fit any known diagnosis in 6 large animal vets knowledge or books on hand. One goat with high parasite load (no he didn't spit out the dewormer) but almost absent eosinophil count. 

There is a large part of me that wishes I had sent Yukon to the university for a necropsy but being my favorite I couldn't stand the thought. He was my favorite, my best friend. Of all the creatures I've lost, none have ever hurt this deeply. 

Again the order the symptoms happened: high fever (6-7 days), lethargy, violent tremors, inappetance, dehydration, renal failure, sudden drop in rbc, rapid decline in wbc. Yukon had a few unique symptoms in comparison to the other 3 sick goats: never started to get better, diarrhea, rapid weight loss, weakness, staggering, loss of balance and coordination, odd vocalization (distant minded).
And the treatment: Antibiotic A, Banamine, cold hosing, Thiamine, Nuflor, IV fluids, B12 Inj, Oxytetracycline, Ivermectin.

I can't believe it's been 27 days since this all started. We had many plans with the goats in July and August that were all increasing in length and difficulty but now that get to have a "staycation" and walk the yard with me. We hope to bring the boys out to some easier trails once we are cleared since our weekly conditioning has ceased temporarily. I hope to soon post a happy "we made it" photo for this thread. 

Any and all thoughts and idea's are welcomed. 

I got a photo of Yukon printing on metal with rounded corners for the barn, her it is, Yukon watching over his brother Huck. 

[img]IMG_20170723_181256 by Kataya Uren, on Flickr[/img]

In memory of Yukon, and on the left Yota my african fat tailed gecko she passed a week before this all started. 
[img]IMG_20170725_160859 by Kataya Uren, on Flickr[/img]