Chat
07-21-2014, 09:29 PM
(This post was last modified: 07-22-2014, 05:57 PM by Dave-Trinity-Farms.)
Just going to add some blurbs from the cydectin (CATTLE POUR ON) analysis read out.
Mode of Action
Moxidectin is an endectocide in the milbemycin chemical class which shares the distinctive mode of action characteristic of macrocyclic lactones. CYDECTIN (moxidectin) Pour-On is specially formulated to allow moxidectin to be absorbed through the skin and distributed internally to the areas of the body affected by endo- and/or ectoparasitism. Moxidectin binds selectively and with high affinity to glutamate-gated chloride ion channels which are critical to the function of invertebrate nerve and muscle cells. This interferes with neurotransmission resulting in paralysis and elimination of the parasite.
Yes, pour ons are used orally all the time. But this is, and I quote "specially forumulated to allow moxidectin to be absorbed through the skin"
Dosage
CYDECTIN (moxidectin) Pour-On is a ready-to-use topical formulation intended for direct application to the hair and skin in a narrow strip extending along the top of the back from the withers to the tailhead (see Figure 1). Due to the angular topline characteristic of most dairy breeds, it is recommended that all pour-on products be applied slowly to dairy cows. Apply to healthy skin avoiding any mange scabs, skin lesions, mud or manure. Treated cattle can be easily recognized by the characteristic purple color, which will remain for a short period of time after treatment. The recommended rate of administration is 1 mL for each 22 lb (10 kg) body weight which provides 0.5 mg moxidectin for each 2.2 lb (0.5 mg/kg) body weight.
Precautions
For external use only. Do not apply to areas of skin with mange scabs, skin lesions, mud or manure. Cydectin Pour-On is not recommended for use in species other than cattle. This product has been formulated specifically for topical use in cattle and should not be used in other animal species or by other routes of administration as adverse reactions may occur. Cydectin Pour-On is effective against the migrating stage of cattle grubs (Hypoderma larvae). Treatment with Cydectin Pour-On during the period when grubs are migrating through vital areas may cause undesirable host-parasite reactions. Killing H. lineatum when they are located in peri-esophageal tissues may cause bloat. Killing H. bovis when they are in the vertebral canal may cause staggering or hindlimb paralysis. Cattle should be treated as soon as possible after heel fly (warble fly) season to avoid this potential problem. Cattle treated with Cydectin Pour-On at the end of fly season can be re-treated during the winter without danger of grub-related reactions. Consult your veterinarian for more information regarding these secondary grub reactions and the correct time to treat with Cydectin Pour-On.
Dwite spoke of the pour on having more of Moxidectin and indeed he was right in that the bottle contains more of it. Not the does. The break down is as follows: The amount of moxidectin the animal gets at recommended cattle does (which still needs to be increased across the board on all 3 types) per 110 lbs is 1ml for the injectable, 5ml for the pour on and 10ml for the drench. Which means the injectable is the strongest forum with the pour on being 5x diluted and the drench being 10 times diluted. But in the end, each method delivers the same amount of moxidectin per lb because of the recommended dosing. The issue then comes in to how each is designed to be administered and the inactive ingredients. Costs reflect this with the injectable being the cheapest until you factor in needles and syringes which puts it on par with the pour on. So we can now focus on the Pour On and the Drench. But here is the problem with that. There is no cattle doesage for the sheep drench but as with everything else if there were, it would equal out how much each animal got of Moxidectin.
Now here is where it gets interesting. As mentioned goats need 2-4 times the cattle dosage because goats metabolize faster then cattle and have a much more active rumin. I challenge anyone to do a search for goat vs cattle doses. On every forum and every page of long standing knowledgeable goat people and websites you will see, dosages are indeed increased. Call up a livestock vet who knows goats and they will tell you the same thing. This is the real life trial and error I spoke of. But the key difference (after some research) as mentioned above is how each method is specifically designed to be used. Dwite says his source of knowledge says to use the pour on. Well the pour on, the carrier in it, is kerosene based. NO, i dont not mean they use kerosene but a chemical in the same family that is close to kerosene. Thus the smell. Just like Ivormecin is alcohol based. There is also a water resistant chemical in the pour on. This helps to keep the pour on in place long enough for the carrier to help the skin absorb the moxidectin. And finally, the purple dye. Which is simply meant to give a visual to the farmer which animal has been done. There is no research on this dye that I can find of yet but again, something else potentially not good to put into your goat. Now on the other hand, you have the drench which is designed to be taken orally. Designed to be gentler on the animals rumin. No harsh chemical carrier. No unknown dye. The only reason people use the pour on as an oral is the price. Its the cheapest way to go. That and it can actually burn the goats skin.
Mode of Action
Moxidectin is an endectocide in the milbemycin chemical class which shares the distinctive mode of action characteristic of macrocyclic lactones. CYDECTIN (moxidectin) Pour-On is specially formulated to allow moxidectin to be absorbed through the skin and distributed internally to the areas of the body affected by endo- and/or ectoparasitism. Moxidectin binds selectively and with high affinity to glutamate-gated chloride ion channels which are critical to the function of invertebrate nerve and muscle cells. This interferes with neurotransmission resulting in paralysis and elimination of the parasite.
Yes, pour ons are used orally all the time. But this is, and I quote "specially forumulated to allow moxidectin to be absorbed through the skin"
Dosage
CYDECTIN (moxidectin) Pour-On is a ready-to-use topical formulation intended for direct application to the hair and skin in a narrow strip extending along the top of the back from the withers to the tailhead (see Figure 1). Due to the angular topline characteristic of most dairy breeds, it is recommended that all pour-on products be applied slowly to dairy cows. Apply to healthy skin avoiding any mange scabs, skin lesions, mud or manure. Treated cattle can be easily recognized by the characteristic purple color, which will remain for a short period of time after treatment. The recommended rate of administration is 1 mL for each 22 lb (10 kg) body weight which provides 0.5 mg moxidectin for each 2.2 lb (0.5 mg/kg) body weight.
Precautions
For external use only. Do not apply to areas of skin with mange scabs, skin lesions, mud or manure. Cydectin Pour-On is not recommended for use in species other than cattle. This product has been formulated specifically for topical use in cattle and should not be used in other animal species or by other routes of administration as adverse reactions may occur. Cydectin Pour-On is effective against the migrating stage of cattle grubs (Hypoderma larvae). Treatment with Cydectin Pour-On during the period when grubs are migrating through vital areas may cause undesirable host-parasite reactions. Killing H. lineatum when they are located in peri-esophageal tissues may cause bloat. Killing H. bovis when they are in the vertebral canal may cause staggering or hindlimb paralysis. Cattle should be treated as soon as possible after heel fly (warble fly) season to avoid this potential problem. Cattle treated with Cydectin Pour-On at the end of fly season can be re-treated during the winter without danger of grub-related reactions. Consult your veterinarian for more information regarding these secondary grub reactions and the correct time to treat with Cydectin Pour-On.
Dwite spoke of the pour on having more of Moxidectin and indeed he was right in that the bottle contains more of it. Not the does. The break down is as follows: The amount of moxidectin the animal gets at recommended cattle does (which still needs to be increased across the board on all 3 types) per 110 lbs is 1ml for the injectable, 5ml for the pour on and 10ml for the drench. Which means the injectable is the strongest forum with the pour on being 5x diluted and the drench being 10 times diluted. But in the end, each method delivers the same amount of moxidectin per lb because of the recommended dosing. The issue then comes in to how each is designed to be administered and the inactive ingredients. Costs reflect this with the injectable being the cheapest until you factor in needles and syringes which puts it on par with the pour on. So we can now focus on the Pour On and the Drench. But here is the problem with that. There is no cattle doesage for the sheep drench but as with everything else if there were, it would equal out how much each animal got of Moxidectin.
Now here is where it gets interesting. As mentioned goats need 2-4 times the cattle dosage because goats metabolize faster then cattle and have a much more active rumin. I challenge anyone to do a search for goat vs cattle doses. On every forum and every page of long standing knowledgeable goat people and websites you will see, dosages are indeed increased. Call up a livestock vet who knows goats and they will tell you the same thing. This is the real life trial and error I spoke of. But the key difference (after some research) as mentioned above is how each method is specifically designed to be used. Dwite says his source of knowledge says to use the pour on. Well the pour on, the carrier in it, is kerosene based. NO, i dont not mean they use kerosene but a chemical in the same family that is close to kerosene. Thus the smell. Just like Ivormecin is alcohol based. There is also a water resistant chemical in the pour on. This helps to keep the pour on in place long enough for the carrier to help the skin absorb the moxidectin. And finally, the purple dye. Which is simply meant to give a visual to the farmer which animal has been done. There is no research on this dye that I can find of yet but again, something else potentially not good to put into your goat. Now on the other hand, you have the drench which is designed to be taken orally. Designed to be gentler on the animals rumin. No harsh chemical carrier. No unknown dye. The only reason people use the pour on as an oral is the price. Its the cheapest way to go. That and it can actually burn the goats skin.